Pilot study of intravenous melphalan combined with continuous infusion L-S,R-buthionine sulfoximine for children with recurrent neuroblastoma

Anderson Clarke P.; Matthay Katherine K.; Perentesis John P.; Neglia Joseph P.; Bailey Howard H.; Villablanca Judith G.; Groshen Susan; Hasenauer Beth; Maris John M.; Seeger Robert C.; Reynolds C. Patrick

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Pilot study of intravenous melphalan combined with continuous infusion L-S,R-buthionine sulfoximine for children with recurrent neuroblastoma

机译：静脉美法仑联合连续输注L-S，R-丁硫氨酸亚砜亚胺治疗小儿复发性神经母细胞瘤的初步研究

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PurposeTo evaluate BSO-mediated glutathione (GSH) depletion in combination with L-PAM for children with recurrent or refractory high-risk neuroblastoma (NB) as a means to enhance alkylator sensitivity.

机译：目的为评估复发性或难治性高危神经母细胞瘤（NB）患儿的BSO介导的谷胱甘肽（GSH）消耗与L-PAM的结合，以提高烷化剂敏感性。

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来源
《Pediatric blood & cancer》 |2015年第10期|共8页
作者
Anderson Clarke P.; Matthay Katherine K.; Perentesis John P.; Neglia Joseph P.; Bailey Howard H.; Villablanca Judith G.; Groshen Susan; Hasenauer Beth; Maris John M.; Seeger Robert C.; Reynolds C. Patrick;
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正文语种 eng
中图分类儿科学;
关键词
glutathione; melphalan; neuroblastoma; reactive oxygen species;

机译：谷胱甘肽;美法仑;神经母细胞瘤;活性氧;

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1. Pilot study of intravenous melphalan combined with continuous infusion L-S,R-buthionine sulfoximine for children with recurrent neuroblastoma [J] . Anderson Clarke P., Matthay Katherine K., Perentesis John P., Pediatric blood & cancer . 2015,第10期

机译：静脉美法仑联合连续输注L-S，R-丁硫氨酸亚砜亚胺治疗小儿复发性神经母细胞瘤的初步研究
2. Inhibition of glutathione production by L-S,R-buthionine sulfoximine activates hepatic ascorbate synthesis - A unique anti-oxidative stress mechanism in mice [J] . Yu Miao, Liu Ying, Duan Yajun, Biochemical and Biophysical Research Communications . 2017,第1期

机译：L-S，R-苯胺磺酰昔亚胺对谷胱甘肽产生的抑制激活肝抗坏血酸合成 - 小鼠的独特抗氧化应激机理
3. The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: a video-intracranial electroencephalographic study. [J] . Wang Y, Zaveri HP, Lee T Experimental Neurology . 2009,第2期

机译：大鼠连续海马内注入甲硫氨酸亚砜亚胺后发作性癫痫的发展：一项视频脑电图研究。
4. EFFICACY OF ONDANSETRON CONTINUOUS INFUSION AND BOLUS INTRAVENOUS FOR POSTOPERATIVE NAUSEA AND VOMITING [C] . Rina Saputri, Abdul Rahem, Anita Purnamayanti Sari Mulia International Conference on Health and Sciences . 2018

机译：术术术后恶心和呕吐的ondansetron连续输注和推注的疗效
5. A Phase I Study of Fenretinide (LXS) Lym-X-Sorb(TM) Oral Powder in Patients with Recurrent or Resistant Neuroblastoma. [D] . Marachelian, Araz. 2013

机译：Fenretinide（LXS）Lym-X-Sorb（TM）口服粉剂用于复发性或耐药性神经母细胞瘤患者的I期研究。
6. Dosing Evaluation of Continuous Intravenous Fentanyl Infusions in Overweight Children: A Pilot Study [O] . Emily C Gish, Donald Harrison, Andrew K Gormley, 2011

机译：超重儿童持续静脉注射芬太尼的剂量评估：一项初步研究
7. Phase I Study of Continuous-Infusion L-S,R-Buthionine Sulfoximine With Intravenous Melphalan [O] . Howard H. Bailey, Kendra D. Tutsch, Rhoda Z. Arzoomanian, 2013

机译：连续输注L-s，R-丁硫氨酸亚砜亚胺与静脉注射美法仑的I期研究
8. Intravenous Toxicity of L-Buthionine Sulfoximine (NSC-326231) and Its Effect on Melphalan (NSC-8806) Induced Toxicity in Mice [R] . Liao, J. T. , Collins, W. T. , Rodwell, D. E. 1988

机译：L-丁硫氨酸亚砜亚胺（NsC-326231）的静脉毒性及其对美法仑（NsC-8806）诱导小鼠毒性的影响

Pilot study of intravenous melphalan combined with continuous infusion L-S,R-buthionine sulfoximine for children with recurrent neuroblastoma

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