Efficient Synthesis of N-3-Substituted 6-Aminouracil Derivatives via N~6-[(Dimethylamino)mehylene]Protection

摘要

A convenient synthetic procedure has been developed to introduce different functional groups at position 3 of 6-amino-1-benzyl- or 6-amino-1-methyluracil based on N~6[(dimethylamino)methylene]protection.This method allows for the smooth substitution at N-3 even when base-labile or heat sensitive halide reagents are employed.