Stereoselective Total Synthesis of Bioactive Styryllactones: 9-Deoxygoniopypyrone, Goniopypyrone and 7-epi-Goniofufurone

摘要

Stereoselective synthesis of the bioactive styryllactones (+)-9-deoxygoniopypyrone, (+)-goniopypyrone and (+)-7-epi-goniofufurone has been achieved from d-(-)-tartaric acid. The key step involves the elaboration of a trihydroxy ester to the title compounds utilizing high-yielding stereoselective transformations.