Synthesis of Fe_2O_3 nanoparticles via various methods and coating with silica for drug immobilization

摘要

Synthesis of Fe_2O_3 nanoparticles was investigated using precipitation and thermal decomposition methods. Ammonia and urea, as alkali materials, were used in precipitation method. For comparison, Fe_ 2O_3 nanoparticles was prepared from thermal decomposition method in 2-hydroxy ethyl ammonium formate and 1,2-propan diol as solvent. The SEM images show that thermal decomposition method in presence of surfactant gives the best result for Fe_2O_3 nanoparticles. These particles were coated with silica and then the citallopram hydrobromid was immobilized on coated nanoparticle surface. TEM images show the silica layer on Fe_2O_3 nanoparticles and immobilization of the drug was proved from the FT-IR spectrum.