SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION, AND BIOLOGICAL ACTIVITY OF N-ISONICOTINOYL-N'-THIOBENZOYLHYDRAZINE COMPLEXES OF Co(II), Ni(II), Cu(ii), and Zn(II)

摘要

A new ligand, N-isonicotinoyl-N'-thiobenzoylhydrazine (HINTB), has been prepared by the reaction of isonicotinic acid hydrazide and carboxymethyl dithiobenzoate. The addition complexes [M(HINTB)_2Cl_2] [M - Co(II), Ni(II), Zn(II), [Cu(HINTB)Cl_2] M(HINTB)_2(CH_3COO)_2 [M = Co(II), Ni(II)] and deprotonated complexes [Cu(INTB)(CH_3COO)] and (Zn(INTB)_2) have been prepared and characterized by elemental analyses, magnetic susceptibility, electronic, NMR and IR spectral data. The room temperature ESR spectra of [Cu(HINTB)Cl_2] and [Cu(INTB)(CH_3COO)] are characteristic of monomeric and dimeric species, respectively. The ligand and the complexes have been screened for activity against a number of fungi and bacteria.