Facilitation of Lordosis Behaviour is Differential Mediated by 5-HT2 Receptor Agents in Diazepam-Tolerant Female Rats

摘要

Diazepam-tolerant but ovariectomized rats were primed with 50 ug oestradiol benzoate and 500 (ig progesterone to induce a lordosis quotient of moderate intensity. Enhancing of lordosis was induced by treating with 5-HT2A/2C receptor agonist, DOI. The effect of the 5-HT2c receptor antagonist, ketanserin and the 5-HT2A receptor antagonist, ritanserin, on lordosis behaviour were investigated in ovariectomized but steroids-primed diazepam-tolerant rats. Both ketanserin and ritanserin inhibited lordosis behaviour. A potent protective effect of DOI was noted following antagonists ketanserin and ritanserin treatment. DOI attenuated the lordosis inhibiting effect of ritanserin-injected to diazepam-toferant rats. These data show that diazepam-tolerance as such did not cause significant change in the lordosis profile. Behavioural profile as a consequence of ritanserin and DOI treatment further reinforce the prior inference that facilitation of female lordosis behaviour is differentially mediated by 5-HT2 receptor agents and tolerance to anxiolytic does not alter the lordosis profile, significantly.