Efficacy of a Combination of Emodepside plus Praziquantel against Larval and Adult Stages of Nematodes (Trichuris muris, Angiostrongylus cantonensis) in Rodents

摘要

A combination of emodepside plus praziquantel was tested in laboratory mice strain C57BL/10 experimentally infected with Trichuris muris. Under the conditions chosen, a single topical administration of 3.0 mg emodepside per kg of body weight (bw) and 12.0 mg praziquantel per kg bw at day 52 led to a survival rate of 6.8% of mature T. muris at 54 day post infection (dpi). Using the same dose at 3 dpi, the survival rate of mature nematodes at 52 dpi was 84.7%. However, when single treatment with 3.0 mg emodepside per kg bw plus 12.0 mg praziquantel per kg bw was used at 20 dpi or 35 dpi, the survival rates of adult nematodes on day 52 were 15.7 or 18.8%, respectively. Following a single administration of 6 mg emodepside per kg bw and 24 mg praziquantel per kg bw at 3, 20 and 35 dpi the survival rates of mature T. muris were 1.7, 0.6 or even 0%.