Synthesis, biological evaluation, and molecular docking studies of new pyrazol-3-one derivatives with aromatase inhibition activities

摘要

A new series derived from 4-(2-chloroacetyl)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one was synthesized, characterized and its pharmacological activity toward aromatase enzyme inhibition was screened and compared to the reference native ligand letrozole. The most active compound of the series was 16, showing IC50 value of 0.0023 +/- 0.0002m compared to letrozole with IC50 of 0.0028 +/- 0.0006m. In addition, compounds 26 and 36 exhibit good inhibition activities close to letrozole with IC50 values 0.0033 +/- 0.0001 and 0.0032 +/- 0.0003m, respectively. Moreover, molecular docking studies were conducted to support the findings.