Assessing the subjective and physiological effects of intranasally administered crushed extended-release morphine formulations with and without a sequestered naltrexone core in recreational opioid users

Setnik Beatrice; Goli Veeraindar; Levy-Cooperman Naama; Mills Catherine; Shram Megan; Smith Ira

首页> 外文期刊>Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur >Assessing the subjective and physiological effects of intranasally administered crushed extended-release morphine formulations with and without a sequestered naltrexone core in recreational opioid users

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Assessing the subjective and physiological effects of intranasally administered crushed extended-release morphine formulations with and without a sequestered naltrexone core in recreational opioid users

机译：在娱乐性阿片类药物使用者中评估含和不含纳曲酮核心的鼻内镇静缓释吗啡制剂的镇痛作用

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OBJECTIVE: To evaluate the pharmacodynamic (PD) effects of morphine sulfate and naltrexone hydrochloride extended-release (MSN) capsules compared with controlled-release morphine sulfate (MS) and placebo when crushed and administered intranasally.

机译：目的：与经控释的硫酸吗啡（MS）和安慰剂相比，当吗啡和盐酸纳曲酮缓释（MSN）胶囊经鼻内压碎和鼻腔给药时，其药效学（PD）效果如何。

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《Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur》 |2013年第4期|共8页
作者
Setnik Beatrice; Goli Veeraindar; Levy-Cooperman Naama; Mills Catherine; Shram Megan; Smith Ira;
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原文格式 PDF
正文语种 eng
中图分类麻醉学;
关键词
Abuse potential; Drug liking; Intranasal administration; Morphine; Naltrexone; Pharmacodynamic; Pharmacokinetic;

机译：滥用潜力;喜好药物;鼻内给药;吗啡;纳曲酮;药效学;药代动力学;
入库时间 2022-08-18 15:28:31

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1. Assessing the subjective and physiological effects of intranasally administered crushed extended-release morphine formulations with and without a sequestered naltrexone core in recreational opioid users [J] . Setnik Beatrice, Goli Veeraindar, Levy-Cooperman Naama, Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur . 2013,第4期

机译：在娱乐性阿片类药物使用者中评估含和不含纳曲酮核心的鼻内镇静缓释吗啡制剂的镇痛作用
2. Intranasal Administration of Crushed ALO-02 (Extended-Release Oxycodone With Sequestered Naltrexone): A Randomized, Controlled Abuse-Potential Study in Nondependent Recreational Opioid Users [J] . The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2015,第12期

机译：粉碎的ALO-02（隔离型纳曲酮的扩展释放羟考酮）的鼻内给药：非依赖性休闲类鸦片使用者的随机，受控滥用潜能研究
3. Assessment of pharmacodynamic effects following oral administration of crushed morphine sulfate and naltrexone hydrochloride extended-release capsules compared with crushed morphine sulfate controlled-release tablets and placebo in nondependent recreational opioid users [J] . SetnikB., SommervilleK., GoliV., Pain medicine : . 2013,第8期

机译：非依赖性休闲阿片类药物使用者对硫酸吗啡和盐酸纳曲酮缓释胶囊与硫酸吗啡控释片剂和安慰剂相比口服给药后的药效学评估
4. Assessing the subjective and physiological effects of intranasally administered crushed extended-release morphine formulations with and without a sequestered naltrexone core in recreational opioid users [O] . Beatrice Setnik, Veeraindar Goli, Naama Levy-Cooperman, 2013

机译：在娱乐性阿片类药物使用者中评估含和不含纳曲酮核心的鼻内镇静缓释吗啡制剂的镇痛作用
5. Human Abuse Potential of an Abuse-Deterrent (AD), Extended-Release (ER) Morphine Product Candidate (Morphine-ADER Injection-Molded Tablets) vs Extended-Release Morphine Administered Intranasally in Nondependent Recreational Opioid Users [O] . Lynn R. Webster, Michael D. Smith, John Lawler, 2016

机译：滥用滥用（AD），延长释放（ER）吗啡产品候选（吗啡 - 涂剂注塑片剂）与鼻内诊断娱乐阿片类药物鼻内施用的延长释放吗啡（ER）吗啡潜在

Assessing the subjective and physiological effects of intranasally administered crushed extended-release morphine formulations with and without a sequestered naltrexone core in recreational opioid users

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