Metal-halogen exchange using tri-n-butyl lithium magnesate in the diazine series: Diazine 49

摘要

We report herein the 'metal-halogen exchange' reaction in the diazine series with lithium tri-n-tributylmagnesate. The reaction was performed with 2-iodopyrazine, 2-methylsulfanyl-4-iodopyrimidine and 3-iodo-6-phenylpyridazine. Benzophenone, aldehydes and diphenylsulfur were used as electrophiles affording alcohols and phenylsulfanyl derivatives with satisfactory to good yields.