Development of new asymmetric reactions utilizing tartaric acid esters as chiral auxiliaries. The design of an efficient chiral multinucleating system

摘要

A practical method for the construction of chiral molecules has been designed using a novel strategy based on systems possessing multiple metal centers and tartaric acid esters as chiral auxiliaries. By using this design, we have developed methods for carrying out highly enantioselective (1) Simmons-Smith reaction, (2) 1,3-dipolar cycloaddition reactions of nitrile oxides and nitrones, and (3) nucleophilic additions of organometallic compounds to imine derivatives. [References: 90]