Manganese(III) acetate-mediated alkylation of 1,3-dicarbonyls to form tricarbonyl compounds bearing a quaternary carbon centre

摘要

1,3-Dicarbonyl compounds including ethyl 2-methylacetoacetate can be efficiently alkylated with enol ethers or enol esters in the presence of manganese(III) acetate. These intermolecular radical addition reactions can be used to form sterically congested quaternary carbon centres in excellent yield (81-97%). [References: 34]