RBD and antidepressants

摘要

Their prior findings of high rates of RBD symptoms among psychiatric patients taking seroto-nergic antidepressants [3] concur with the findings in our case ser-,: ies [2] and other reports [4], and we read with interest their follow-up study with polysomnographic confirmation, which is critical for distinguishing RBD from its multiple mimics. The intriguing finding that, despite a decrease in subjective dream enactment episodes with antidepressant change or discontinuation, there was persistent REM without atonia (RWA) noted objectively on polysomnogram [1], lends further credence to a contributory role of antidepressants in RBD and RWA in susceptible individuals. However, studies with polysomnograms before and after antidepressant initiation, demonstrating RBD occurring as a consequence of antidepressants, are still lacking. We certainly agree that further investigation is necessary in this area, particularly as antidepressant usage becomes increasingly widespread. Additionally, long-term follow-up studies are required to determine any relationship between antidepressant-related RBD and neurodegenerative disease.