Patho-physiology of restless legs syndrome: A very tedious puzzle!

摘要

The diagnosis of restless legs syndrome (RLS) is currently based on the presence of specific clinical symptoms. There are no objective tests for RLS, largely because the patho-physiology is unclear, and its primum movens is unknown. Previous work on the patho-physiology of RLS suggests an involvement of multiple systems: brain structures, major biochemical and neurotransmitter systems, spinal cord pathways and the peripheral nervous system [1,2].