Which Genome Variants Matter?

摘要

Findings published recently in Science will accelerate the search for genes involved in human disease.The report provides a first genome-wide view of how the unique composition of genetic variation within each of us leads to unique patterns of gene activity.By defining those genetic variants with a biological effect,the results will help to prioritise regions of the genome that are investigated for association with disease.This is an important step to understanding links between genes and disease for individuals,and across populations.