Highly regioselective synthesis of ethyl 2-(N-methylformate-1,4,5,6- tetrahydropyridin-2-yl) acetate and its conversion into corresponding (R)-ethyl homopepicolate by asymmetric hydrogenation

摘要

Ethyl 2-(N-methylformate-1,4,5,6-tetrahydropyridin-2-yl) acetate with endocyclic double bond was prepared with high regioselectivity and further reduced into (R)-N-protected homopipecolate with a good enantioselectivity using chiral ruthenium catalyst.