AN IMPROVED REDUCTION PROCEDURE IN THE SYNTHESIS OF SUBSTITUTED PYRROLIDINES VIA AN AMINOMERCURATION REDUCTION SEQUENCE OF PRIMARY ALKENYLAMINES

摘要

Aminomercuration/reduction sequence of delta-alkenylamines is a typical route to substituted pyrrolidines. Backward reaction to the starting material is a major drawback which occurs during sodium borohydride reduction of the intermediate organomercurial. We describe here a new reduction procedure which prevents almost completely this backward reaction and leads to significant increases in the yields of pyrrolidines. [References: 44]