Burst of autoimmunity with the emergence of primary Sjogren syndrome, cholestatic autoimmune hepatitis and latent autoimmune diabetes of adults (LADA).

摘要

Primary Sjogren syndrome (pSS) is a systemic autoimmune disorder characterized by the simultaneous presence of keratoconjunctivitis sicca and xerostomia in the absence of other connective tissue diseases. Although pSS is an autoimmune exocri-nopathy, the involvement of nonexo-crine organs, such as the liver, kidneys and lungs, has been reported. Autoimmune hepatitis (AIH) and primary biliary cirrhosis are the most common liver diseases coinciding with pSS.1 Cho-lestasis is a rare finding in AIH. Latent autoimmune diabetes in adults (LADA) is the type of diabetes in adults which is initially noninsulin requiring but with immune markers of Type 1 diabetes that often progress to insulin dependence.2 We report a patient who presented with the symptoms and findings of pSS, cholestatic AIH and LADA at the same time.