Bleomycin plasma spill-over levels in paediatric patients undergoing intralesional injection for the treatment of haemangiomas.

摘要

To the Editor: Haemangiomas are the most common tumours of infancy. Although most are symptomless, some cause serious complications related to their anatomical location or biological behaviour and therefore require treatment. The beneficial effect of intralesional bleomycin infiltration (IBI) in the treatment of haemangiomas has been reported. The Pretoria Vascular Malformation Study Group evaluated the effectiveness of IBI treatment in 37 patients with haemangiomas. Complete resolution or significant improvement occurred in 87% of patients with an extremely low side-effect profile, reported complications mainly including local pain and transient flu-like symptoms.