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Liver tumours in children: Current surgical management and role of transplantation

机译:儿童肝肿瘤:当前的外科治疗和移植的作用

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This article reviews the current surgical management of liver tumours in children in the light of improved chemotherapy, surgical techniques and outcomes from transplantation. It is a principle of management that complete removal of a tumour must be achieved for cure. Neoadjuvant chemotherapy may downstage advanced local disease to enable safe curative tumour resection. When this is not achievable, transplant is indicated. Conventional indications for transplant are unresectable stages 3 and 4 tumours confined to the liver. With the realisation that lifelong immunosuppressive therapy has considerable adverse consequences, there has been a recent trend towards extreme and 'acrobatic' liver resection to avoid transplantation, but still obtain a cure. The current literature is reviewed in the light of these trends and our own experience.
机译:本文根据改良的化学疗法,手术技术和移植的结果,回顾了目前儿童肝肿瘤的外科治疗方法。管理的原则是必须完全清除肿瘤才能治愈。新辅助化疗可能会降低晚期局部疾病的发生率,从而能够安全治愈肿瘤。如果无法实现,则需要进行移植。移植的常规指征是局限于肝脏的不可切除的3和4期肿瘤。认识到终生免疫抑制疗法会产生相当大的不良后果,最近出现了一种极端的和“杂技”肝脏切除术以避免移植但仍能治愈的趋势。根据这些趋势和我们自己的经验对当前文献进行了回顾。

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