Inhibition of Fibril Formation of by Guanidiniocarbonyl Pyrrole Receptors

摘要

Alzheimer's disease(AD)is a progressive neurodegenerative disorder.Pathology visible"post mortem"includes neurode-generation and extracellular deposition of amyloids,both in neuritic plaques and diffuse deposits.The major proteina-ceous component of AD amyloids is the amyloid-beta protein(Abeta),a protein consisting of 39-42 amino acids derived from the Alzheimer precursor protein(APP).