Sensitive Determination of Tinidazole Using Glassy Carbon Electrode Coated with Multi-walled Carbon Nanotube/ ionic Liquid/chitosan Composite Film

摘要

A multi-walled carbon nanotube/1-butyl-3-metliylimidazolium tetrafluoroborate/chitosan (MWCNT/IL/CS) composite film - modified glassy carbon electrode (GCE) was fabricated by spin coating. Electrochemical behavior of tinidazole at the composite film electrode was investigated applying voltammetry. A distinct reduction peak located at ca -0.688 V was observed during potential cycling in the range from 0.200 V to -1.00 V. Compared to its voltammetric behavior on bare GCE, the reduction peak potential of tinidazole was shifted positively and the peak current significantly increased. All experimental parameters for electrochemical determination of tinidazole were optimized. The detection limit and linear calibration range were 1.00 x 10~(-7) mol L~(-1) (S/N = 3) and 3.00 x 10~(-7) to 2.00 x 10~(-5) mol L~(-1), respectively. In addition, using the proposed film electrode determination of tinidazole in real tablets was carried out with satisfactory results.