Soluble CD146 boosts therapeutic effect of endothelial progenitors through proteolytic processing of short CD146 isoform

Stalin Jimmy; Harhouri Karim; Hubert Lucas; Garrigue Philippe; Nollet Marie; Essaadi Amel; Muller Alexandre; Foucault-Bertaud Alexandrine; Bachelier Richard; Sabatier Florence; Pisano Pascale; Peiretti Franck; Leroyer Aurelie S.; Guillet Benjamin; Bardin Nathalie; Dignat-George Francoise; Blot-Chabaud Marcel

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Soluble CD146 boosts therapeutic effect of endothelial progenitors through proteolytic processing of short CD146 isoform

机译：可溶性CD146通过短CD146异构体的蛋白水解加工来增强内皮祖细胞的治疗效果

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Endothelial colony-forming cells (ECFC) constitute an endothelial progenitor fraction with a promising interest for the treatment of ischaemic cardiovascular diseases. As soluble CD146 (sCD146) is a new factor promoting angiogenesis, we examined whether sCD146 priming could improve the therapeutic potential of ECFC and defined the involved mechanism.

机译：内皮集落形成细胞（ECFC）构成内皮祖细胞级分，对缺血性心血管疾病的治疗具有广阔的前景。由于可溶性CD146（sCD146）是促进血管生成的新因子，因此我们研究了sCD146引发是否可以提高ECFC的治疗潜力，并确定了涉及的机制。

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《Cardiovascular Research》 |2016年第3期|共12页
作者
Stalin Jimmy; Harhouri Karim; Hubert Lucas; Garrigue Philippe; Nollet Marie; Essaadi Amel; Muller Alexandre; Foucault-Bertaud Alexandrine; Bachelier Richard; Sabatier Florence; Pisano Pascale; Peiretti Franck; Leroyer Aurelie S.; Guillet Benjamin; Bardin Nathalie; Dignat-George Francoise; Blot-Chabaud Marcel;
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正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
Angiogenesis; Apoptosis; Endothelial progenitor; Hindlimb ischaemia; SPECT-CT;

机译：血管生成;凋亡;内皮祖细胞;Hindlimb缺血;SPECT-CT;

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专利

1. Soluble CD146 boosts therapeutic effect of endothelial progenitors through proteolytic processing of short CD146 isoform [J] . Stalin Jimmy, Harhouri Karim, Hubert Lucas, Cardiovascular Research . 2016,第3期

机译：可溶性CD146通过短CD146异构体的蛋白水解加工来增强内皮祖细胞的治疗效果
2. CD146 short isoform increases the proangiogenic potential of endothelial progenitor cells in vitro and in vivo. [J] . Kebir A, Harhouri K, Guillet B, Circulation research: a journal of the American Heart Association . 2010,第1期

机译：CD146短同种型在体外和体内增加内皮祖细胞的常规潜力。
3. CD146 short isoform increases the proangiogenic potential of endothelial progenitor cells in vitro and in vivo. [J] . Kebir A, Harhouri K, Guillet B, Circulation research: a journal of the American Heart Association . 2010,第1期

机译：CD146短同种型在体外和体内增加内皮祖细胞的常规潜力。
4. Therapeutic application of endothelial progenitor cells for ischemia [C] . Osamu Masuo, Takayuki Asahara International Symposium on Mechanobiology of Cartilage and Chondrocyte . 2002

机译：内皮祖细胞缺血的治疗应用
5. Manipulating Endothelial Progenitor Cell Homing with Sphingosine-1-Phosphate for Therapeutic Angiogenesis. [D] . Williams, Priscilla Anne. 2016

机译：鞘氨醇-1-磷酸处理内皮祖细胞归巢治疗血管生成。
6. Soluble Melanoma Cell Adhesion Molecule (sMCAM/sCD146) Promotes Angiogenic Effects on Endothelial Progenitor Cells through Angiomotin [O] . Jimmy Stalin, Karim Harhouri, Lucas Hubert, 2013

机译：可溶性黑素瘤细胞粘附分子（sMCAM / sCD146）通过血管动蛋白促进对血管内皮祖细胞的血管生成作用。
7. Soluble CD146 boosts therapeutic effect of endothelial progenitors through proteolytic processing of short CD146 isoform [O] . Jimmy Stalin, Karim Harhouri, Lucas Hubert, 2016

机译：可溶性CD146通过短CD146同种型的蛋白水解加工提高内皮祖细胞的治疗效果
8. Proteolytic Processing of the Protease Which Initiates Degradation of Small, Acid-Soluble Proteins during Germination of Bacillus subtilis Spores [R] . Sanchez-Salas, J. L., Setlow, P. 1993

机译：蛋白酶的蛋白水解加工促进枯草芽孢杆菌孢子萌发过程中小酸性蛋白质的降解

Soluble CD146 boosts therapeutic effect of endothelial progenitors through proteolytic processing of short CD146 isoform

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