Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia: Reply

摘要

We thank Steele et al. for their interest and comments regarding our recent study focusing on the effects of l_Na reduction on spontaneous sarcoplasmic reticulum (SR) Ca~(2+) release.In the context of the authors' previous publications regarding the mechanism of action of fle-cainide at the cardiac ryanodine receptor (RyR2), it appears they have interpreted our study as an attempt to infer that flecainide has no effect on RyR2. We would like to clarify this misinterpretation.