Perception is the element of the diagnostic process that we are most likely to ignore. Indeed, by its very nature, deficiency of perception is imperceptible. It is also culturally difficult for a trained professional to admit that he or she is consistently and predictably fallible. Only through rigorous and systematic inquiry can shortcomings in perception be appreciated and strategies to improve accuracy devised. There are many aspects to perception, and they interface with clinical imaging in a myriad of ways. We have endeavored to include major topics, especially those that relate to nuclear medicine, in this issue of Seminars.
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