Biologic scaffolds for constructive tissue remodeling.

摘要

The extracellular matrix (ECM) represents the secreted products of the resident cells of each tissue and organ and is in a state of dynamic reciprocity with these cells [1].The tissue specific 3-dimensional organization of the structural and functional molecules of which the ECM is composed has not been fully characterized; therefore, creation of a synthetic analog is not possible. Biologic scaffold materials composed of ECM have been manufactured from many different tissues such as dermis, small intestine, urinary bladder, heart, trachea and lung and from a variety of species including human, porcine, bovine and equine [2-8] by methods of decellularization and sterilization that aim to retain maximum functionality of biologically active molecules while removing cellular antigens which may cause an adverse host immune response [9-11].