KdmA, a histone H3 demethylase with bipartite function, differentially regulates primary and secondary metabolism in Aspergillus nidulans

摘要

Work in Austria was founded by the Austrian Science Fund FWF grant F3703-B22, by the Vienna Science and Technology Fund Project LS-09-042 and by grant LS12-009 from the n(f+b) Lower Austria Science Fund. Work in Australia was funded by grants from the Australian Research Council and Howard Hughes Medical Institute to AA, and by the Spanish Ministerio de Ciencia e Innovacion (BFU2008-04306) for work performed by AM in the laboratory of David Canovas. Microarray slides and experimental protocols were provided by the Pathogen Functional Genomics Resource Center (PFGRC) through NIAID, deletion cassettes by the Fungal Genetics Stock Centre. We thank the Oakley and Aguirre laboratories for strains, and Q. Lang for photography. We are grateful to Joan Tilburn and David Canovas for helpful discussions on penicillin production, light regulation and for critically reading the manuscript.