Discussion Addendum for: Efficient Synthesis of Halomethyl-2,2'-Bipyridines: 4,4'- Bis(Chloromethyl)-2,2'-Bipyridine

摘要

Halogenation of dimethyl-2, 2'-bipyridines via trimethylsilyl (TMS) intermediates and electrophilic halide reagents, CX3CX3 (X = Cl, Br or F), is a very useful method for bipyridine (bpy) derivation.2"4 This approach is benefits from nearly quantitative yields, few by-products, and low cost reagents. In the past decade, there have been only a few improvements reported for this reaction, but many bipyridine derivatives have been prepared using this method. Many bipyridine analogues have been accessed via TMS-bpy intermediates.