RECENT PROGRESS IN THE SYNTHESIS OF LABDANE DITERPENOIDS.A REVIEW

摘要

Labdane diterpenoids have a bicyclic framework illustrated in the basic skeleton below and are the most common diterpenoids,which are widely distributed in terrestrial as well as marine organisms.Recent progress on the isolation of labdane diterpenoids are compiled in the review by Hanson.Biogenetically,cyclization of geranylgeranylpyrophosphate provides the bicyclic framework of labdane diterpenoids.In contrast to other diterpenoids,there is less structural diversity in labdane diterpenoids.In most of these compounds,the relative stereochemistry of the ring junctures is trans.With regard to the absolute stereochemistry,there are two enantio-series.Some of these compounds exhibit a wide range of biological properties such as anti-mutagenic,anti-bacterial and anti-fungal,cytotoxic,anti-inflammatory and analgesic activities,etc.