Oral immediate and prolonged release oxycodone for safe and effective patient controlled analgesia after surgery Can opioid for acute postoperative pain be improved by adding a peripheral opioid antagonist?

摘要

In this issue of the Scandinavian Journal of Pain Boel Niklasson and co-workers, report a pragmatic study on pain relief in patients after Caesarean Section (CS). They compared a regimen with oral immediate and prolonged release oxycodone with the standard of care at Karolinska University Hospital, Huddinge [1], Standard of care at the time at Huddinge was intravenous (IV) morphine administered by nurses during the first 24 h after a CS and thereafter with codeine-containing tablets. Both groups received ibuprofen and paracetamol.