OXIDATIVE DECARBOXYLATION AND DEAMINATION OF GLYCINE, ALANINE AND VALINE BY N-IODOSUCCINIMIDE IN AQUEOUS ACETIC ACID MEDIUM. A KINETIC STUDY

摘要

The kinetics of oxidation of glycine, alanine and valine using N-iodosuccinimide in acetic acid-water medium in the presence of hydrochloric acid at 303 K has been studied. The reaction shows inverse first order with respect to oxidant and [H+]. Increase in [amino acid] has a slight positive effect on the rate, indicating first order dependence. Addition of salts like K2SO4, Na2SO4, KC1 to the reaction medium has no effect on the rate, increase in temperature increases the rate of the reaction. The amino acids were oxidised to corresponding aldehydes, carbon dioxide, and ammonia. The products obtained were isolated and identified. The activation parameters have been computed. A mechanism confirming to the kinetic observations is suggested.