Antibacterial ciprofloxacin HC1 incorporated polyurethane composite nanofibers via electrospinning for biomedical applications

摘要

We report on the preparation and characterization of polyurethane (PU) composite nanofibers by electrospinning. Two different approaches were adopted to obtain the PU composite nanofibers. In the first approach, a homogeneous solution of 10wt% PU containing ciprofloxacin HC1 (CipHCl) drug was electrospun to obtain PU/Drug composite nanofibers. And in the second approach, the PU with ciprofloxacin HC1 drug and ceramic hydroxyapatite (HA) particles were electrospun to obtain the PU/Drug and PU/Drug/HA composite nanofibers. The surface morphology, structure, bonding configuration, optical and thermal properties of the resultant products were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and UV-vis spectroscopy. The antibacterial activity was tested against common food borne pathogenic bacteria, namely, Staphylococcus aureus, Escherichia coll by the minimum inhibitory concentration (MIC) method. Our result results demonstrate that these composite nanofibers possess superior characteristics which can utilized for variety of applications.