Abstracts of the Osteoporosis Conference 2010. November 28-December 1, 2010. Liverpool, United Kingdom.

摘要

Treatment is commonly directed on the basis of bone mineral density (BMD). In the UK, treatment has been recommended by the Royal College of Physicians (RCP) when the T-score for BMD is found to be less than -2.5 SD of with a prior fragility fracture. More recently, the National Institute for Health and Clinical Excellence (NICE) has provided intervention thresholds also based on BMD. The same T-score has, however, quite a different significance at different ages. For example, the 10-year probability of hip fracture for women in the UK with a T-score of -3 SD is 3.2% at the age of 50 years, but 19.8% at the age of 80 years. Thus, fracture risk prediction is optimised by integrating information on risk factors that contribute to fracture risk independently of BMD.