Asymmetric Deactivation of Racemic BINAP-Ru(II) Catalysts through Complete Enantiomer Discrimination by Dimethylbinaphthylamine: Highly Enantioselective Hydrogenation of Olefin and β-Keto Ester

摘要

3,3'-Dimethyl-2,2'-diamino-1,1'-binapthyl (DM-DABN) is designed as a "chiral poison" (deactivator) for complete enantiomer resolution of racemic BINAP-Ru(II) catalysts in a highly enantioselective hydrogenation of β-keto ester and kinetic resolution of racemic 2-cyclohexen-1-ol.