Pd-Catalyzed Selective Addition of Heteroaromatic C-H Bonds to C-C Triple Bonds under Mild Conditions

摘要

Simple heteroarenes such as pyrroles and indoles undergo addition reactions to C-C triple bonds in the presence of a catalytic amount of Pd(OAc)_2 under very mild conditions, affording cis-heteroarylalkenes in most cases. The cleavage of aromatic C-H bonds is the possible rate-determining step in CH_2Cl_2, and the addition of heteroaromatic C-H bonds to C-C triple bonds is in a trans-fashion.