A Novel Chiral Pentamine Ligand fro Enantioselective #alpha#-Alkylation of Acyclic Lithium Amide Enolates. Optimization of Chiral Ligands for Asymmetric Reactions Using Solid-Phase Organic Synthesis

摘要

A novel pentamine ligand has been developed for enantioselective #alpha#-alkylation of simple acyclic lithium amide enolates. It has been demonstrated that solid-phase organic synthesis provides a powerful and rapid method for finding efficient chiral ligands.