Convenient, in Situ Generation of Anhydrous Hydrogen Iodide for the Preparation of α-Glycosyl Iodides and Vicinal Iodohydrins and for the Catalysis of Ferrier Glycosylation

摘要

Anhydrous hydrogen iodide is generated in situ by the reaction of solid iodine and a thiol. The HI thus generated has been employed for the efficient preparation of α-glycosyl iodides and vicinal iodohydrins from the corresponding glycosyl acetates and epoxides, respectively, and for Ferrier glycosylation of alcohols and thiols.