Design,Synthesis,and Biological Evaluation of Potent Discodermolide Fluorescent and Photoaffinity Molecular Probes

摘要

The design,synthesis,and biological evaluation of a series of (+)-discodermolide molecular probes possessing photoaffinity and fluorescent appendages has been achieved.Stereoselective olefin cross-metathesis comprised a key tactic for construction of two of the molecular probes.Three photoaffinity probes were radiolabeled with tritium.