Ionic liquid as catalyst and reaction medium. The dramatic influence of a task-specific ionic liquid, [bmlm]OH, in Michael addition of active methylene compounds to conjugated ketones, carboxylic esters, and nitriles

摘要

A task-specific ionic liquid, [bmlm]OH, has been introduced as a catalyst and as a reaction medium in Michael addition. Very interestingly, although the addition to alpha,beta-unsaturated ketones proceeds in the usual way, giving the monoaddition products, this ionic liquid always drives the reaction of open-chain 1,3-dicarbonyl compounds with alpha,beta-unsaturated esters and nitriles toward bis-addition to produce exclusively bis-adducts in one stroke.