Highly Selectiv eIntra- and Intermolecula rcouplign Reactions o fDiazo Compound sto Form cis-Alkenes using a Ruthenium Porphyrin Catalyst

摘要

[Ru(2,6-Cl_2TPP)(CO)]catalyzed intramolecular couplign reactions of bisdiazolacetates and intermolecular coupling reactiosn of monodiazoacetates to afford the coupling products in up to 76% and 93% yields,respectively.Only the cis isomers were obtained form the reacitons.Employing such a ruthenium- catalyzed coupling reaciton of a diazo compound as a key step allowed th esynthesis of Pautlolide B in 67% yield iwth a ratio of >40:1 against its trans isomer.