Studies in macrolide antibiotic synthesis: The role of tethered alkoxides in titanium alkoxide-mediated regioselective reductive coupling reactions

摘要

A convergent route to a C1-C15 fragment precursor for erythromycin-based macrolide antibiotics is presented. These studies define a role for tethered alkoxides in the control of site-selective carbon-carbon bond formation in titanium alkoxide-mediated coupling reactions of internal alkynes and chiral aldehydes.