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首页> 外文期刊>Biological & pharmaceutical bulletin >Inhibition of hydrogen peroxide, nitric oxide and TNF-alpha production in peritoneal macrophages by ethyl acetate fraction from Alchornea glandulosa.
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Inhibition of hydrogen peroxide, nitric oxide and TNF-alpha production in peritoneal macrophages by ethyl acetate fraction from Alchornea glandulosa.

机译:拟南芥中乙酸乙酯成分对腹膜巨噬细胞中过氧化氢,一氧化氮和TNF-α产生的抑制作用。

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The effects of Alchornea glandulosa ethyl acetate fraction (AGF) on hydrogen peroxide (H2O2), nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) production in peritoneal macrophages activated with lipopolysaccharide (LPS) or phorbol myristate acetate (PMA) were investigated. Analysis by thin layer chromatography (TLC) of AGF showed several constituents, including flavonoids, which may have anti-inflammatory activity. Inhibitory effects of the fraction in H2O2 and NO production ranged from 8.59+/-7.84% to 70.56+/-4.16% and from 16.06+/-3.65% to 38.73+/-3.90%, respectively. The TNF-alpha production was only partially inhibited in the tested concentrations (12.21+/-6.23% - 15.16+/-0.96%). According to these results, it is suggested that AGF has anti-inflammatory activity. This medicinal plant may have therapeutic potential in the control of inflammatory disorders.
机译:脂多糖(LPS)或佛波肉豆蔻酸酯乙酸酯(PMA)激活的腹膜巨噬细胞中,腺体醋酸乙酯组分(AGF)对过氧化氢(H2O2),一氧化氮(NO)和肿瘤坏死因子-α(TNF-α)的影响)进行了调查。通过AGF的薄层色谱(TLC)分析显示了几种成分,包括类黄酮,它们可能具有抗炎活性。该馏分对H2O2和NO产生的抑制作用分别为8.59 +/- 7.84%至70.56 +/- 4.16%和16.06 +/- 3.65%至38.73 +/- 3.90%。在测试浓度(12.21 +/- 6.23%-15.16 +/- 0.96%)中,TNF-α的产生仅被部分抑制。根据这些结果,表明AGF具有抗炎活性。这种药用植物在控制炎症方面可能具有治疗潜力。

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