Engineering Grp170-based immune modulators for cancer immunotherapy.

摘要

We have recently demonstrated that glucose-regulated protein 170 (Grp170), astress-responsive molecular chaperone of the endoplasmic reticulum, can beexploited to stimulate anticancer immunity due to its superior antigenchaperoning and delivering capacity. The immune remodeling of the tumormicroenvironment induced by a Grp170-based chaperone leads to immune responsesthat effectively control the progression of both primary neoplasms and theirmetastases. Our findings support the development of Grp170-based immunomodulatingstrategies to potentiate antitumor immune responses.