An apolipoprotein A-I mimetic targets scavenger receptor A on tumor-associatedmacrophages: A prospective anticancer treatment?

摘要

Tumor-associated macrophages polarize toward an M2 phenotype and expressscavenger receptor A (SRA), hence promoting tumor progression. We demonstratedthat SRA can be therapeutically targeted in vivo with the small peptide inhibitor4F to prevent metastatic spread. Beyond our study, 4F is emerging as a promising anticancer agent.