Formation of bovine serum albumin associates with zinc tetra(4,4'- carboxy)phenylamino- and tetra-(4,4'-carboxy)phenoxy phthalocyanines in aqueous-organic solutions at 298 K

摘要

The states of water-soluble complexes of zinc phthalocyanine containing -O-C_6H_4-COONa and -NH-C_6H_4-COONa substituents in aqueous and organic media are studied. The type of dimerization is determined for each phthalocyanine. Phthalocyanine interaction with bovine serum albumin is studied with respect to the association equilibria. It is shown that phthalocyanines are localized in protein subdomains IB and IIA, and the interaction between protein and phthalocyanines is of a multicenter character.