Regioselective Reduction of 1H-Pyrrole-2,3-diones with Thioacetamide

摘要

The addition of primary amines to carbon atoms in the positions 2 and 5 of 1-aryl-4-aroyl-5-methoxycarbonyl- H-pyrrole-2,3-diones is described [1,2]; the reactions of these pyrrolediones with amides and thioamides are not studied. On melting l-aryl-4-benzoyl-5-methoxycarbonyl-1H-pyrrole-2,3-diones la, lb with thioacetamide (II) we obtained 1-aryl-4-benzoyl-3-hydroxy-5-methoxycarbonyl-2,5-dlhydro-1H-pyrrol-2-ones IIIa, IIIb.