Heterocyclizatioes of Functionalized Heterocurauleneswith C,N-, C,O-, and C,S-Binucleophiles: XIII.Synthesis of Bialkyl 2-Oxo-3-allyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates and Their Reaction with Arylhydroxymoyl Chlorides

摘要

Dialkyl 2-oxo-3-allyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates obtained by condensation of 1-chlorobenzyl isocyanates with N-allylfumarates reacted regioselectively with arylhydroxymoyl chlorides with the formation of dialkyl 6-aryl-3-[(3-aryl-4,5-dihydro-5-isoxazolyl)methyl]-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates.