-Oh no! hiPSCs misplace their 5hmCs.

摘要

hiPSCs and hESCs are thought to display subtle genetic and epigenetic variability. Recently in Nature Cell Biology, Wang et?al. (2013) demonstrated a role for TET1 during reprogramming of human cells and showed that hiPSCs lack appropriate 5hmC marks in subtelomeric regions, contributing to epigenetic variation common to hiPSCs.