The Survival Detriment of Venous ? Thromboembolism With Epithelial Ovarian Cancer

摘要

More than 10% of cancer patients have venous thromboembolism (VTE). There is a clear relationship between VTE and several types of solid tumors; VTE negatively impacts survival. This disorder is the second leading cause of death in cancer patients. Some studies have reported that the solid tumor with the highest rate of VTE is ovarian cancer. Few studies have evaluated the contribution of VTE timing to survival in patients with solid tumors. A substantial proportion of deaths in cancer patients may be preventable with improved and tailored thromboprophylaxis. The aim of this retrospective study was to evaluate the effect of VTE on survival in patients with epithelial ovarian cancer (EOC) and to determine how the chronology of VTE events with respect to surgery impacts survival. A chart review was performed for data from patients treated for EOC [at a single medical center between 1996 and 2011]. Associations between VTE and the primary outcomes of progression-free survival (PFS) and overall survival (OS) were assessed using a Cox proportional hazards model. Data were adjusted for diagnosis, age, stage, histology, performance status, and residual disease.