Fever in pregnancy and offspring mortality: A longitudinal study of a cohort from 1927 to 1937 on the faroe Islands

摘要

Adverse influences in utero may have a causal relationship with adult health. Size at birth appears to be associated with morbidity and mortality later in life, and a number of reports have suggested that infections occurring during pregnancy may be associated with preterm birth or stillbirth and other adverse perinatal effects as well as the subsequent development of disease in adults. This cohort study investigated the relationship between pregnancy complications, specifically fever in utero, and adult health in a birth cohort comprised of individuals born during 1927-1937 in an isolated island community with high birth weight. Complete medical records including maternal data, complications during pregnancy and birth, and newborn data were extracted from medical registries. Dates of death and identifiable ICD-recorded causes of death were also extracted. Multiple Cox regression was used for mortality analyses.